vicissitudes [vəˈsɪsəˌtjudz]

例句:

• A man used to vicissitudes is not easily dejected.
  饱经沧桑,不易沮丧.
  
• He experienced several great social vicissitudes in his life.
  他一生中经历了几次大的社会变迁.
  
• The vicissitudes of life may suddenly make a rich man very poor.
  在人世的沧桑中,一个有钱人突然也会变成穷光蛋.
  
• Policymakers too often pretend that they've mastered the vicissitudes of economic life.
  来自THETIMES
• Remarkable climatic vicissitudes during past ages.
  来自R. S. Ball
• Respect for the rule of law must mean something, irrespective of the vicissitudes of political cycles.
  来自VOA