The synthesis of cyclo ( - Ab 7 - Aib - Phe - D - Pro - ) which uses solid phase peptide synthesis with N - Fmoc protection is faild.
本论文尝试用固相法氨基酸N端Fmoc保护策略合成cyclo ( -Ab7-Aib-Phe-D-Pro- ).但是最终产物经ESI-MS分析不是目标产物,故改用液相法合成目标化合物.
The coupling reaction between the difficult sequence Fmoc - Arg ( Pbf ) - OH and H - Pro - Trt resin was investigated.
着重研究了 Fmoc -Arg ( Pbf ) -OH与H -Pro-Trt 树脂的缩合反应.
Fmoc, Boc and Pbf were used respectively to protect α - amido, side amido and side guanidine group.
对于α-氨基仍采用Fmoc保护策略, 侧链氨基用二碳酸二叔丁酯引入叔丁氧羰基来保护,侧链胍基用酸敏感保护基2,2, 4,6,7-五甲基二氢苯并呋喃-5-磺酰基来保护.