Rapamycin arrested cell cycle in G 1 phase to antitumor by degrading the CDK - cyclin complexes kinase activity.
Rapamycin还能通过降低CDK-cyclin复合物激酶的活性,使细胞周期阻滞在G1期,从而发挥抗肿瘤的作用.
Cyclin - cdk compound is composed of Cyclin and cdk different cell cycle.
多种肿瘤存在着Cyclin的异常表达,cdk的激活及其抑制因子的丢失.
CDK activation by cyclin binding.
1)CDKs结合cyclin后活化.